Sodium Borohydride Pharmaceutical Intermediates For Reduction Of Carbonyl Compounds / Whatsapp:+8615308670259

Basic Info

Name:Sodium borohydride 

EINECS:241-004-4

Molecular Formula:NaBH4

CAS: 16940-66-2

Synonyms:SBH; Sodium tetrahydroborate; Sodiumborohydridepowder; Sodiumborohydrideonneutralalumina; Sodiumborohydridepellets; Sodiumborohydridetablets; Sodiumborohydridewhitepowder; Sodium tetrahydridoborate

Chemical Properties

Appearance:white crystalline powder

Molecular Weight:37.83

Density:1.07

Boiling Point:500°C

Melting Point:400ºC (dec.)

Flash Point:69ºC

Storage Temperature:Store at RT.

Water solubility: 550 g/L (25 °C)

Stability:Stability Stable, but reacts readily with water (reaction may be violent). Incompatible with water, oxidizing agents, carbon dioxide, hydrogen halides, acids, palladium, ruthenium and other metal salts, glass. Flammable solid. Air-sensitive.

Description;

Sodium borohydride is a white to grayish crystalline powder. It is decomposed by water to form sodium hydroxide, a corrosive material, and hydrogen, a flammable gas. The heat of this reaction may be sufficient to ignite the hydrogen. The material itself is easily ignited and burns vigorously once ignited. It is used to make other chemicals, treat waste water, and for many other uses.

Sodium borohydride (NaBH4) is the most commonly available borohydride, synthesized by reacting methylborate with sodium hydride in mineral oil. It is employed as a precursor for producing other metal borohydrides. Various approaches for qualitative and quantitative monitoring of sodium borohydride have been explained.

Applications:

1. The principal application of sodium borohydride is the production of sodium dithionite from sulfur dioxide: Sodium dithionite is used as a bleaching agent for wood pulp and in the dyeing industry.

2. Sodium borohydride reduces aldehydes and ketones to give the related alcohols. This reaction is used in the production of various antibiotics including chloramphenicol, dihydrostreptomycin, and thiophenicol. Various steroids and vitamin A are prepared using sodium borohydride in at least one step.

3. Sodium borohydride is used as reducing agent in the synthesis of gold nanoparticles.

Sodium borohydride has been considered as a solid state hydrogen storage candidate. Although practical temperatures and pressures for hydrogen storage have not been achieved, in 2012 a core-shell nanostructure of sodium borohydride was used successfully to store, release and reabsorb hydrogen under moderate conditions.

4. Sodium Borohydride also been used as Pharmaceutical intermediate, the synthesis of drug and fine chemicals, bleaching of paper pulp, recycling of noble metal, avoid the pollution of heavy metal, plasticizer, dyeing, anti-dirt, catalyst, the tail gas transformer, used in reducing, refining, decolor and oxidization of peroxide, the pollution control and recycling of metal in photo and meat process industry, the making and catalyst recycling of medicine and fine chemicals. 

Uses:

Pharmaceutical intermediate, the synthesis of drug and fine chemicals, bleaching of paper pulp., recycling of noble metal, avoid the pollution of heavy metal, plasticizer, dyeing, anit-dirt, catalyst, the tail gas transformer, used in reducing, refining , decolor, deodor,, and oxidization of peroxide, the pollution control and recycling of metal in photo and meat process industry, the making and catalyst recycling of medicine and fine chemicals,

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