Lidocaine base details

Product name: Lidocaine

Other name: Xylocaine

CAS: 137-58-6

MF: C14H22N2O

MW: 234.34

EINECS: 205-302-8

Usage: Antiarrhythmic Agents, Anesthetics

Anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state.

Lidocaine HCL details

Product name: Lidocaine HCL
Full name: Lidocaine hydrochloride
CAS: 73-78-9
MF: C14H23ClN2O
MW: 270.8
Product Categories: API’s
Usage: Local anesthesic;Na+ channel blocker
Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.

Lidocaine description :

Lidocaine is a local anesthetic, also known as seocaine, in recent years has replaced procaine, widely used in cosmetic plastic surgery for local infiltration anesthesia, it inhibits nerve cell membrane sodium channels play a resistance Off nerve excitability and conduction. The liposoluble protein binding rate is higher than procaine, penetrating cell ability, fast onset, long duration of action, the intensity of procaine is 4 times.

Clinical application in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia, reduce the toxicity of lidocaine and other side effects, can be added in the anesthetic epinephrine.

Lidocaine can also be used for the treatment of acute myocardial infarction ventricular premature beats, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and Ventricular fibrillation. Followed by the state of epilepsy is also used for other anticonvulsants ineffective and local or spinal anesthesia. But is usually ineffective for supraventricular arrhythmias.

Lidocaine HCl description:

Lidocaine hydrochloride because of local anesthetics and antiarrhythmic drugs. Mainly used for clinical anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. Can also be used for acute myocardial infarction ventricular premature beats and ventricular tachycardia, can also be used for digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias. But is usually ineffective for supraventricular arrhythmias.

Lidocaine hydrochloride because of amide local anesthetic. Blood absorption or intravenous administration of the central nervous system have obvious excitement and inhibition of biphasic effects, and can be without the excitement of the pioneer, low blood concentration, the emergence of analgesia and drowsiness, increased pain threshold; with the dose plus Large, role or increased toxicity, sub-toxic plasma concentrations of anticonvulsant effect when the plasma concentration of more than 5μg ml-1 can occur seizures. Lidocaine hydrochloride in low doses, can promote myocardial K + outflow, reduce myocardial autonomy, and has anti-ventricular arrhythmias; at the therapeutic dose, the electrical activity of myocardial cells, atrioventricular conduction and myocardial Contraction no significant effect; blood concentration further increased, can cause heart conduction velocity, atrioventricular block, inhibition of myocardial contractility and cardiac output decreased.

Lidocaine HCL Application :

Lidocaine hydrochloride has a strong penetration, dispersion and strong, fast onset of the characteristics of anesthetic efficacy of 2 times and procaine, and toxicity of 1. 5 minutes after treatment can occur anesthetic effect, anesthesia for 1 to 1.5 hours sustainable, 50% longer than procaine. Absorption can inhibit the central nervous system, and can inhibit ventricular autonomy, shortening refractory period, can be used as control of ventricular tachycardia, treatment of premature ventricular contractions, ventricular tachycardia and ventricular fibrillation and other arrhythmia symptoms. On the heart itself or cardiac arrhythmias caused by cardiac arrhythmia are effective, supraventricular tachycardia is ineffective. This product is fast, short duration, oral invalid, often as intravenous administration.

Lidocaine HCL Application :

• Infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block.

• Treatment of acute myocardial infarction (AMI) after ventricular premature beats and ventricular tachycardia, and digitalis poisoning, cardiac surgery, cardiac catheterization-induced ventricular arrhythmias, but usually not effective for supraventricular arrhythmias.

Lidocaine HCl Specification

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